International Scientific Conference Košice Miskolc. New Trends in Experimental and Clinical Neuroscience - PDF

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European Union European Regional Development Fund Department of Neurosurgery, AD Centre, Pavol Jozef Šafárik University, Faculty of Medicine and University Hospital of Louis Pasteur in Košice, Slovakia

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European Union European Regional Development Fund Department of Neurosurgery, AD Centre, Pavol Jozef Šafárik University, Faculty of Medicine and University Hospital of Louis Pasteur in Košice, Slovakia Department of Neurosurgery, Borsod County Teaching Hospital, Miskolc, Hungary International Scientific Conference Košice Miskolc New Trends in Experimental and Clinical Neuroscience Final Programme and Book of Abstracts Košice, Slovakia 17th September 2010 Európai Unió Európai Regionális Fejlesztési Alap Magyarország-Slovákia Határon Átnyúló Együttmüködési Program Scientific Committee prof. Ladislav Mirossay, M.D., D.Sc. Košice Dr. Csiba Gábor M.D. Miskolc prof. Leonard Siegfried, M.D., Ph.D. Košice Dr. Csókay András M.D., Ph.D Miskolc Ivo Vanický, DVM, PhD. NBI SAV Košice Dr. Oláh Csaba M.D. Miskolc assoc. prof. Zuzana Gdovinová, M.D., Ph.D. Košice Pungor András Ph.D. Miskolc assoc. prof. Miroslav Gajdoš, M.D., Ph.D. Košice prof. Molnár Péter M.D., D.Sc. Debrecen assoc. prof. Imrich Lukáč, M.D., Ph.D. Košice Dobai József, M.D. Miskolc assist. prof. Peter Mach, M.D., Ph.D. Košice Dr.Demeter Béla M.D. Miskolc assist. prof. Igor Šulla, jr., DVM, PhD. UVM Košice Local organization committee prof. Igor J. Šulla, MD, DSc., chairman. assoc. prof. Miroslav Gajdoš, MD, PhD. Ivo Vanický, DVM, PhD. Dr. Nadežda Lukáčová, DSc. assisst. prof. Aurelia Kollová, MD assist. prof. Igor Šulla, jr., DVM, PhD. Reviewers: prof. Miron Šramka, M.D., D.Sc. Bratislava, Slovakia. assoc. prof. František Helcl, M.D., Ph.D., Prague, Czech Republic. Európska Únia Európsky Fond Regionálneho Rozvoja Program Cezhraničnej Spolupráce Maďarská Republika - Slovenská Republika Venue Lecture room of the Pavol Jozef Šafárik University, Faculty of Medicine, tr. SNP 1, Košice. Date 17th September Address for correspondence assoc. prof. Miroslav Gajdoš, M.D., Ph.D. Department of Neurosurgery University Hospital of L. Pasteur Tr. SNP 1, Košice, Slovakia. Registration by an Registratio fee Free Access Deadline for abstract submission 6th September 2010 max. 250 words Deadline for manuscript submission 17th September 2010 max. 5 pages, including figures, graphs, tables and references. Book of Abstracts every participant receives at a registration desk Proceedings of the Conference every participant will receive by the post. European Union European Regional Development Fund Friday, 17th September ,00 Opening ceremony 9,30 10,00 Coffee Break 10,00 Scientific Session I. (Time allocated for presentation 8 min.) Chairmen Csókay András, Igor J. Šulla 1. The Importance of Very Early Decompressive Craniectomy as a Prevention of Sudden Increase of ICP in Children with Severe Traumatic Brain Swelling Csókay, A., Miskolc, Hungary 2. Osteoporotic Vertebral Fractures Gajdoš M., Kaťuch V., Pataky F., Džugan M., Košice, Slovakia. 3. The Effects of Infrared Laser Therapy and Weightbath Traction Hydrotherapy as a Component of Complex Physical Treatment in Disorders of Lumbar Spine: A Controlled Pilot Study with Follow Up. Oláh, Cs., Páll, V., Jancsó, Z., Bender, T., Oláh, M., Miskolc, Debrecen, Budapešť, Hajdúszoboszló, Hungary 4. Risk Factors for Stroke Gdovinová Z., Feketeová E., Košice, Slovakia. 5. Non-Occlusive By-Pass Technique in the Course of Cerebral Revascularization Csókay, A., Miskolc, Hungary. 6. Cavernous Sinus and Parasellar Region from Clinical Point of View Lovásová, K., Boleková, A., Šulla, I.J., Kluchová, D. Košice, Slovakia. 7. Introducing the Nanotechnology Institute Pungor, A., Miskolc, Hungary. 8. Long Term Results of Meningioma Treatment Using Leksell Gamma Knife Kollová, A., Liščák, R., Šemnická, J., Šimonová, G., Vladyka, V., Urgošík, D. Košice, Slovakia, and Prague, Czech Republic Európai Unió Európai Regionális Fejlesztési Alap Magyarország-Slovákia Határon Átnyúló Együttmüködési Program 9. Management of Recanalised Aneurysms Lázár, I., Szólics, A., Oláh, Cs., Miskolc, Hungary 10. Some Immunophenotypic Characteristics of Brain GBMs Balik, V., Šarišský, M., Gál, P., Šulla, I. jr. Košice, Slovakia. Discussion 11,30-12,00 Coffee Break 12,00 Scientific Session II. Chairpersons Zuzana Gdovinová, Oláh Csaba 11. Lessons Drawn from Regular Fresh Cadaver Exercises in Sigmoid Sinus Mobilization Csókay A., Miskolc, Hungary. 12. Chaharacteristics of Daytime Sleepiness in Obstructive Sleep Apnea, Narcolepsy and Secondary Hypersomnias. Feketeová E., Tormášiová M., Gdovinová Z., Košice, Slovakia. 13. Dumbbell Tumors of the Spine: Our Experience Dobai, J. I., Miskolc, Hungary. 14. Development of Cholinergic Neurons in the Rat Spinal Cord is Completed at Third Postnatal Week Boleková, A., Košice, Slovakia. 15. Patient Based Carotid Stenting in More than 70 Year Old Patient Oláh, Cs., Lázár, I., Miskolc, Hungary. 16. A Short Review of the Evolution of Cervical Interbody Spacers Pataky F., Gajdoš M., Kaťuch V., Lacko F., Košice, Slovakia. 17. Spontaneous Cerebellar Haemorrhages: Diagnosis and Therapy Fügedi, L., Miskolc, Hungary 18. Problems with Stability of Adult Rat Bone Marrow Derived Stem/Progenitor Cells Šulla, I. jr., Balik, V., Šarišský, M., Gál, P., Košice, Slovakia. Európska Únia Európsky Fond Regionálneho Rozvoja Program Cezhraničnej Spolupráce Maďarská Republika - Slovenská Republika 19. Surgical Treatment of Spinal Extradural Meningeal Cyst: A Case Report and Short Review Papp, A., Székely, Á., Nagy, D., Csókay, A., Miskolc, Hungary. 20. Our Experience with Vagus Nerve Stimulation (VNS) Therapy in Treatment of Refractory Epilepsy Kollova, A., Tormášiová, M., Bratský, L., Feketeová, E., Košice, Slovakia. Discussion 13,30-14,30 Dinner 14,30 Scientific Session III. Chairmen Dobai József, Miroslav Gajdoš 21. Adjacent Segment Disease of Cervical Spine: Theoretical Overview and Illustrative Case Study. Lacko, F., Pataky, F., Dimunová, L., Košice, Slovakia 22. Unilateral Spinal Cord Injury and its Effect on Changes in NO-cGMP Signalization Capková, Ľ., Dávidová, A., Kucharíková, A., Pavel, J., Lukáčová, N., Košice, Slovakia. 23. Suppression of Reflex Activity and Astrocytes Reaction after Baclofen Treatment of Transected Animals Kucharíková A., Dávidová, A., Capková Ľ., Lukáčová N., Košice, Slovakia. 24. Surgical Treatment of a Complex Lumbo-Sacro-Pelvic Fracture. Case report. Demeter, B., Fügedi, L., Oláh, Cs., Székely, A., Dobai, J. Miskolc, Hungary. 25. Excitation Emission Matrices (EEM) and Constant-Wawelength Synchronous Matrices (CW-SM) of Human Cerebrospinal Fluid Harakaľová, M., Mokrý, M., Kušnír, J., Dubayová, K., Šulla, I. jr., Košice, Slovakia. 26. Spinal Cord Glioblastoma Šulla, I. J., Kendeová, J., Džugan, M., Gál, P., Dimunová, L., Košice, Slovakia. 27. Proliferation Activity in the Spinal Cord Ependyma of Adult Rats Blaško, J., Martončíková, M., Lievajová, K., Račeková, E., Košice, Slovakia. 28. Nursing Care in Patients with Hypertonic Intracerebral Haemorrhage. Dimunová, L., Zamboriová, M., Košice, Slovakia. Discussion 16,00 End of the Conference. European Union European Regional Development Fund The Importance of Very Early Decompressive Craniectomy as a Prevention to Avoid the Sudden Increase of ICP in Children with Severe Traumatic Brain Swelling. Csókay, A. Department of Neurosurgery, Borsod County Teaching Hospital, Miskolc, Hungary Introduction The DC studies have not dealt with the accelerating modality of process so far. The fact experienced in children, that all pathologic process so traumatic brain swelling can also dramatically deteriorate, which leads to rapid incurable rise of ICP and death. Method We report 8 severely head injured children under age of 12. All of them recieved ICP monitored management according to AANS and EBIC guidelines. On admitted CT s space occupaing bleeding weren t detected wich should had been removed surgically. Significant intracranial mass effect and hemorrhages in brainstem were also exclusion criteria. The DC-s were performed with vascular tunnel method. Results Each patients DC were performed, not immediately but within 24 hours after addmission. In 7 cases where DC was performed at ICP=25 mmhg where 3 outcomes were favourable with GOS score 4 and 5, 1 patient GOS 3, 1 patient GOS 2 on follow up. In 2 cases GOS score was 1. The latter two instances we noticed the fact that ICP elevated so rapidly besides proper treatment defined in guidelines. Despite of premedication and decompression carried out in 30 minutes we faced hard dura mater, bilateral dilated fixed pupils, excessively high ICP and cerebral herniation. This brought to think directives over and take greater care for the onset of symptoms or deterioration. This gave the success. In the last case, a very early decompression was performed avoiding the fatal progression of ICP. Conclusions In children whom sustained blunt head injury and CT detects progressive edema, it is worth to perform preventive DC even with ICP mmhg. Because as the most careful observation ICP may rise so rapidly so it is impossible to achieve substantive decompression at the range of reversible brain damages. Many studies have dealt with bridging veins compression and with it s harmful late effect induced by brain protrusion. The vascular tunnel method is issued for 9 years, the efficacy has been demonstrated on venous protection.the use of protection of bridging veins (vascular tunnel) absolutely recommended to avoid not only the secondary cortical venous circulatory disorders, but it also makes DC less invasive due to decreased size of this intervention. European Union European Regional Development Fund Osteoporotic Vertebral Fractures Gajdoš M., Kaťuch V., Pataky F., Džugan M. Department of Neurosurgery, P. J. Šafárik University, Faculty of Medicine and University Hospital of L. Pasteur, Košice, Slovak Republic. Objective Painful osteoporotic vertebral compression fractures (VCFs) are a significant cause of disability in the elderly population. Osteoporotic fractures, particularly of the hip and spine, are associated with premature mortality. The diagnosis of osteoporotic and nonosteoporotic vertebral fractures relies on the observation of vertebral deformation on plain radiographs (vertebral fractures are often termed vertebral collapses). Differential diagnoses include Scheuermann's disease, scoliosis, spondylosis, and Schmorl's nodes. Vertebroplasty and kyphoplasty is accepted as an effective, minimally invasive procedure in terms of immediate pain relief, and for restoration of the premorbid level of daily activities. Authors report on their first experience with the early management of the osteoporotic vertebral fractures with kyphoplasty or vertebroplasty. Methods A retrospective analysis was conducted in 44 patients (24 women and 20 men) whose ages ranged from 55 to 77 years (mean age 70,5). The interval between onset of symptoms and surgical intervention ranged from 3 to 11 weeks. 49 levels were treated. All patients resumed routine activities one day after operation. No major complications were encountered in this clinical series. Conclusions Kyphoplasty (vertebroplasty) is a safe and effective method for the treatment of osteoporotic VCFs. Failure to restore VB height does not seem to interfere with the excellent pain management and good functional outcome provided by this procedure. European Union European Regional Development Fund The Effects of Infrared Laser Therapy and Weightbath Traction Hydrotherapy as a Component of Complex Physical Treatment in Disorders of Lumbar Spine: A Controlled Pilot Study with Follow Up. Oláh, Cs 1, Páll, V 1, Jancsó, Z 2, Bender, T 3, Oláh, M 4 1 Borsod County Teaching Hospital, Miskolc, 2 Debrecen Medical University, Debrecen, 3 Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, 4 Hungarospa Health Resort, Hajdúszoboszló, Hungary Introduction The theapeutic modalities available for the conservative management of chronic lumbar pain included infrared laser therapy and underwater traction, which usefulness is not universally acknowledged. This study was intended to ascertain aní beneficial impact of infrared laser therapy and weightbath treatment on the clinical parameters and quality of patients with lumbar discopathy. Material and methods The study population compresed 54 randomised subject. I. group of 18 patients received only infrared laser therapy to lumbar region and painful Valley points. II. group of 18 subjects each received underwater traction therapy of lumbar spine with add-onn McKenzie exercise and iontophoresis. Th remaining III. group treated with exercise and iontophoresis, served as control. VAS, Oswestry index, SF36 scores, range of motion, neurological findings and thermography were monitored to appraise therapeutic afficacy in lumbar discopathy. MRI scan was done at baseline and after 3 moths follow-up. Results Infrared laser therapy and underwater traction for discopathy achieved significant improvement of all study parameters. Among the controls, significant improvement of only a single parameter was seen in patients with lumbar discopathy. Conclusion Infrared laser therapy and underwater traction treatment effectively mitigate pain, muscle spasms, enhance joint flexibility, and improve the quality of life of patients with lumbar discopathy. European Union European Regional Development Fund Risk Factors for Stroke Gdovinová Z., Feketeová E. Department of Neurology, P.J. Šafárik University, Faculty of Medicine, Košice, Slovak Republic Introduction Atrial fibrillation (AF) is known risk factor for stroke, studies on the relationship between alcohol consumption and stroke have shown partly inconsistent results. Patients and methods Study comprised two groups of patients, 47 patients with atrial fibrillation (group 1) and 134 heavy alcohol drinkers (group 2). In the 1 st group, therapy before stroke and stroke consequences were studied. In the 2 nd group, blood flow velocity (Vmean) in cerebral arteries by transcranial doppler and erythrocyte deformability (ED) were measured after admission to hospital and 2 weeks after withdrawal. Mean age of patients was 47 years and all of them drank more than 84 g of alcohol ( g) daily. Results In the 1 st group, only in 3 patients (6,4%) anticoagulants were used before stroke. Poor functional outcome occured in14 (29,8%) of the patients, 2 (4,3%) patients died. Only in 22 (46,8%) of the patients functional outcome was very good, in 9 (19,1%) patients mild improvement was present. In the group of heavy alcohol drinkers significantly decreased Vmean and ED were found after admission to hospital. But, while Vmean was significantly increased after 14 days withdrawal, ED showed very small change. Conclusions Insufficient anticoagulant therapy of AF is the reason of poor outcome of patients after stroke. We suppose that decreased blood flow velocity could be the reason of increased risk for stroke in heavy alcohol drinkers. Changes in blood flow velocity after withdrawal revealed, that velocity is probably more influenced by rehydratation during withdrawal than by changes in erythrocyte deformability. European Union European Regional Development Fund Non-Occlusive By-Pass Technique in the Course of Cerebral Revascularization Csókay, A. Department of Neurosurgery, Borsod County Teaching Hospital, Miskolc, Hungary Introduction The physiological tremor may cause difficulties in microsurgery, in spite of using armrest. The new fingertip support technique consists of the I-II-III fingertip support, on bridge (Bethlehem bridge) above the operation area, reduces the tremor at the end of instruments. Methods Exact measure of tremor reduction was performed. Last year 35 high precise microsurgical cases were operated on by the fingertip support technique. One of the most important application of fingertip support technique to perform non occlusive by pass procedures even if the diameter of recipient vessel not less than 1mm. Results The tremors of the operating hand reduces to quarter and the number of complications have decreased effectively. The cadaver non occlusive by pass study by vaso-vasal shunt or tangentional clipping, prove the evidence of significant advantage of fingertip support technique. The non occlusive by pass could be performed by fingertip support technique from 1.0 mm diameter of recipient vessels. Conclusion By this technique the high and extreme precise microsurgical work has become more effective. It could provide the possibility to reassess of by bass in stroke therapy and routinely perfection of non occlusive by pass during giant aneurysm, parasellar tumors, AVM microsurgery. By fingertip support could be also possible to perform the by pass of bridging veins which eliminate the problem of double key hole during interhemispheric approach to expose the deep axial pathology (tu, AVM, pericallosal aneurysm). European Union European Regional Development Fund Cavernous Sinus and Parasellar Region from Clinical Point of View Lovásová K 1, Boleková A 1, Šulla I. J. 2, Kluchová D 1 1 Department of Anatomy, P. J. Šafárik University, Faculty of Medicine, Košice, 2 Department of Neurosurgery, AD Centre, P. J. Šafárik University, Faculty of Medicine, Košice, Slovak Republic The parasellar region is a space on the both sides of sella turcica, which contains cavernous sinus - complex of chambers separated by the fibrous trabeculae, thus, they have the appearance of a cavern. The cavernous sinus also contains important neurovascular structures as: the internal carotid artery, oculomotor, trochlear, and abducent nerves, as well as the first (ophthalmic) and the second (maxillary) divisions of trigeminal nerve with the trigeminal (Gasser's) ganglion. The abducent nerve runs through the central part of cavernous sinus, whereas other nerves are more lateral. Cavernous sinus receives drainage from the superior ophthalmic vein, which runs through the superior orbital fissure into it. The parasellar region, traditionally referred as the cavernous sinus consists of three distinct compartments: orbital, pterygopalatine, and lateral sellar. Knowledge of the hypophyseal and parasellar anatomy is important to understand the indications and expectations associated with a possible surgery in the middle cranial fossa. The lateral sellar compartment is an anatomically complex region where a number of neoplastic, inflammatory, infectious, and vascular diseases can develop. Therefore the interest of anatomists and radiologists about it is still very attracted in this time. Although the cavernous sinus represents the most relevant parasellar structure, from the practical and clinical point of view all the structures that surround the sella turcica can be included in the parasellar region. The study was supported by the grant KEGA 3/7291/09 European Union European Regional Development Fund Introducing the Nanotechnology Institute Pungor, A. BAYNANO Institute for Nanotechnology, Miskolc, Hungary. The BAYNANO Institute for Nanotechnology was established in Miskolc in 2006 with the support of the NKTH (National Office for Research and Technology), and became a prominent research center of the region with 25 employees and 8-10 students. This is an institute with excellent equipments (including high resolution AFM, SEM, and TEM) and staffs, where more than half of the employees have academic degree. We collaborate with the regional and national universities, small and medium size companies, applying for research grants, developing new methods, and market those. With these collaborations and our high resolution measurement service we could help the companies to solve their quality and technical problems. The Institute utilizing the equipments and knowledge of the staffs is involved in the university education of nanotechnology. Bey
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